c302: a multiscale framework for modelling the nervous system of Caenorhabditis elegans | Zendy

Padraig Gleeson | Zendy; David Lung | Zendy; Radu Grosu | Zendy; Ramin Hasani | Zendy; Stephen Larson | Zendy

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c302: a multiscale framework for modelling the nervous system of Caenorhabditis elegans

Author(s) -

Padraig Gleeson,

David Lung,

Radu Grosu,

Ramin Hasani,

Stephen Larson

Publication year - 2018

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2017.0379

Subject(s) - caenorhabditis elegans , connectome , toolchain , in silico , computer science , neuroscience , biology , model organism , systems biology , model system , nervous system , computational biology , software , functional connectivity , biochemistry , gene , programming language

The OpenWorm project has the ambitious goal of producing a highly detailed in silico model of the nematode Caenorhabditis elegans A crucial part of this work will be a model of the nervous system encompassing all known cell types and connections. The appropriate level of biophysical detail required in the neuronal model to reproduce observed high-level behaviours in the worm has yet to be determined. For this reason, we have developed a framework, c302, that allows different instances of neuronal networks to be generated incorporating varying levels of anatomical and physiological detail, which can be investigated and refined independently or linked to other tools developed in the OpenWorm modelling toolchain.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. elegans at cellular resolution'.

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