The ‘allosteron’ model for entropic allostery of self-assembly | Zendy

Tom McLeish | Zendy; Charley Schaefer | Zendy; A. C. von der Heydt | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The ‘allosteron’ model for entropic allostery of self-assembly

Author(s) -

Tom McLeish,

Charley Schaefer,

A. C. von der Heydt

Publication year - 2018

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2017.0186

Subject(s) - allosteric regulation , nucleation , self assembly , statistical physics , nanotechnology , chemistry , biological system , computer science , materials science , physics , thermodynamics , biology , biochemistry , enzyme

Using the simple 'allosteron' model, we show that it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n -mer protein complexes, and (iii) weakly attractive allosteric interactions in protein-like soft nanoscale objects that can be tuned to define exclusive self-associating families.This article is part of a discussion meeting issue 'Allostery and molecular machines'.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research