A reply to DeVico, Lewis & Gallo (2015)

We appreciate the thoughtful comments provided by DeVico et al. [1] regarding the section of our opinion piece (Wilson u0026 Karp [2]) that discussed the problem of limited durability of HIV-vaccine-induced antibody responses in humans. They have done important work, and written thoughtfully and provocatively about this topic [3]. We share their view that durability of the vaccine-induced antibody response is a key issue and must be addressed as part of the community-wide effort to discover and develop an HIV vaccine that induces protective antibodies and which is practical and affordable for use globally. In our opinion piece, we stated that three studies cited as examples suggest that ‘the duration of anti-HIV envelope antibody responses has not been unusually brief in all studies’, a statement with which they do not agree.