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In their opinion piece [[1][1]], Wilson and Karp discuss the poor durability of the anti-gp120 humoral response, an important feature that poses a significant difficulty for HIV vaccine development [[2][2]]. The authors make the case that short-lived anti-gp120 responses are not seen in all studies

Modulating the durability of anti-HIV gp120 antibody responses after vaccination: a comment on Wilson & Karp (2015)