Evolution of normal and neoplastic tissue stem cells: progress after Robert Hooke | Zendy

Irving L. Weissman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Evolution of normal and neoplastic tissue stem cells: progress after Robert Hooke

Author(s) -

Irving L. Weissman

Publication year - 2015

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2014.0364

Subject(s) - stem cell , biology , cancer stem cell , cd47 , clone (java method) , progenitor cell , microbiology and biotechnology , cancer research , immunology , genetics , antibody , dna

The appearance of stem cells coincides with the transition from single-celled organisms to metazoans. Stem cells are capable of self-renewal as well as differentiation. Each tissue is maintained by self-renewing tissue-specific stem cells. The accumulation of mutations that lead to preleukaemia are in the blood-forming stem cell, while the transition to leukaemia stem cells occurs in the clone at a progenitor stage. All leukaemia and cancer cells escape being removed by scavenger macrophages by expressing the 'don't eat me' signal CD47. Blocking antibodies to CD47 are therapeutics for all cancers, and are currently being tested in clinical trials in the US and UK.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research