Biological challenges to effective vaccines in the developing world | Zendy

Nicholas C. Grassly | Zendy; Gagandeep Kang | Zendy; Beate Kampmann | Zendy

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Biological challenges to effective vaccines in the developing world

Author(s) -

Nicholas C. Grassly,

Gagandeep Kang,

Beate Kampmann

Publication year - 2015

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2014.0138

Subject(s) - immunogenicity , risk analysis (engineering) , management science , medicine , biology , computer science , computational biology , engineering ethics , immunology , engineering , immune system

The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy.

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