Glia selectively approach synapses on thin dendritic spines | Zendy

Nikolai Medvedev | Zendy; V.I. Popov | Zendy; Christian Henneberger | Zendy; Igor Kraev | Zendy; Dmitri A. Rusakov | Zendy; Michael G. Stewart | Zendy

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Glia selectively approach synapses on thin dendritic spines

Author(s) -

Nikolai Medvedev,

V.I. Popov,

Christian Henneberger,

Igor Kraev,

Dmitri A. Rusakov,

Michael G. Stewart

Publication year - 2014

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2014.0047

Subject(s) - dendritic spine , neuropil , postsynaptic potential , neuroscience , postsynaptic density , synapse , dendritic filopodia , biology , spine (molecular biology) , synapse formation , central nervous system , microbiology and biotechnology , excitatory postsynaptic potential , inhibitory postsynaptic potential , receptor , biochemistry , hippocampal formation

This paper examines the relationship between the morphological modality of 189 dendritic spines and the surrounding astroglia using full three-dimensional reconstructions of neuropil fragments. An integrative measure of three-dimensional glial coverage confirms that thin spine postsynaptic densities are more tightly surrounded by glia. This distinction suggests that diffusion-dependent synapse–glia communication near ‘learning’ synapses (associated with thin spines) could be stronger than that near ‘memory’ synapses (associated with larger spines).

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