Long-term depression: a cell biological view | Zendy

Morgan Sheng | Zendy; Ali Ertürk | Zendy

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Long-term depression: a cell biological view

Author(s) -

Morgan Sheng,

Ali Ertürk

Publication year - 2013

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2013.0138

Subject(s) - neuroscience , programmed cell death , synapse , involution (esoterism) , biology , apoptosis , signalling , cell , dendritic spine , microbiology and biotechnology , genetics , consciousness , hippocampal formation

Recent studies of the molecular mechanisms of long-term depression (LTD) suggest a crucial role for the signalling pathways of apoptosis (programmed cell death) in the weakening and elimination of synapses and dendritic spines. With this backdrop, we suggest that LTD can be considered as the electrophysiological aspect of a larger cell biological programme of synapse involution, which uses localized apoptotic mechanisms to sculpt synapses and circuits without causing cell death.

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