On the concept and elucidation of endogenous retroviruses | Zendy

Robin A. Weiss | Zendy

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On the concept and elucidation of endogenous retroviruses

Author(s) -

Robin A. Weiss

Publication year - 2013

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2012.0494

Subject(s) - endogenous retrovirus , biology , genome , endogeny , dna , genetics , vertebrate , provirus , retrovirus , virology , long terminal repeat , virus , host (biology) , gene , endocrinology

Endogenous retrovirus (ERV) genomes integrated into the chromosomal DNA of the host were first detected in chickens and mice as Mendelian determinants of Gag and Env proteins and of the release of infectious virus particles. The presence of ERV was confirmed by DNA hybridization. With complete host genomes available for analysis, we can now see the great extent of viral invasion into the genomes of numerous vertebrate species, including humans. ERVs are found at many loci in host DNA and also in the genomes of large DNA viruses, such as herpesviruses and poxviruses. The evolution of xenotropism and cross-species infection is discussed in the light of the dynamic relationship between exogenous and endogenous retroviruses.

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