Regulation from a distance: long-range control of gene expression in development and disease
Author(s) -
Veronica van Heyningen,
Wendy A. Bickmore
Publication year - 2013
Publication title -
philosophical transactions of the royal society b biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.753
H-Index - 272
eISSN - 1471-2970
pISSN - 0962-8436
DOI - 10.1098/rstb.2012.0372
Subject(s) - biology , gene expression , regulation of gene expression , gene , range (aeronautics) , genetics , disease , evolutionary biology , computational biology , medicine , materials science , composite material , pathology
Regulated gene expression is a major requirement for all living organisms. The requirement for complex spatio-temporal regulation is most obvious during development and differentiation, when precise gene switching choreographs the generation of many different cell types, at the right time and the
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