A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome | Zendy

Miri Krupkin | Zendy; Donna Matzov | Zendy; Hua Tang | Zendy; Markus Metz | Zendy; Rinat Kalaora | Zendy; Matthew J. Belousoff | Zendy; Ella Zimmerman | Zendy; Anat Bashan | Zendy; Ada Yonath | Zendy

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A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome

Author(s) -

Miri Krupkin,

Donna Matzov,

Hua Tang,

Markus Metz,

Rinat Kalaora,

Matthew J. Belousoff,

Ella Zimmerman,

Anat Bashan,

Ada Yonath

Publication year - 2011

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2011.0146

Subject(s) - prebiotic , evolutionary biology , ribosome , biology , computational biology , computer science , cognitive science , communication , neuroscience , genetics , psychology , rna , gene

Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the 'proto-ribosome'. This 'proto-ribosome' could have evolved from an earlier machine that was capable of performing essential tasks in the RNA world, called here the 'pre-proto-ribosome', which was adapted for producing proteins.

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