The meaning of a minuscule ribozyme | Zendy

Michael Yarus | Zendy

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The meaning of a minuscule ribozyme

Author(s) -

Michael Yarus

Publication year - 2011

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2011.0139

Subject(s) - ribozyme , rna , translation (biology) , vs ribozyme , ligase ribozyme , biology , computational biology , hairpin ribozyme , mammalian cpeb3 ribozyme , sequence (biology) , base sequence , evolutionary biology , genetics , messenger rna , dna , gene

The smallest ribozyme that carries out a complex group transfer is the sequence GUGGC-3', acting to aminoacylate GCCU-3' (and host a manifold of further reactions) in the presence of substrate PheAMP. Here, I describe the enzymatic rate, the characterization of about 20 aminoacyl-RNA and peptidyl-RNA products and the pathways of these GUGGC/GCCU reactions. Finally, the topic is evolution, and the potential implications of these data for the advent of translation itself.

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