Progress in the rational design of an AIDS vaccine | Zendy

Gary J. Nabel | Zendy; Peter D. Kwong | Zendy; John R. Mascola | Zendy

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Progress in the rational design of an AIDS vaccine

Author(s) -

Gary J. Nabel,

Peter D. Kwong,

John R. Mascola

Publication year - 2011

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2011.0096

Subject(s) - hiv vaccine , virology , human immunodeficiency virus (hiv) , aids vaccines , biology , computational biology , diversity (politics) , antigen , immunology , vaccine trial , sociology , anthropology

Human immunodeficiency virus-1 (HIV-1) has a high degree of genetic and antigenic diversity that has impeded the development of an effective vaccine using traditional methods. We are attempting to develop an AIDS vaccine by employing strategies that include structural biology and computational modelling, in an effort to develop immunogens capable of eliciting neutralizing antibodies of the requisite breadth and potency against circulating strains of HIV-1.

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