The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing | Zendy

Cynthia Kenyon | Zendy

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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

Author(s) -

Cynthia Kenyon

Publication year - 2010

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2010.0276

Subject(s) - caenorhabditis elegans , biology , mutant , insulin , ageing , insulin receptor , disease , genetics , model organism , evolutionary biology , computational biology , neuroscience , gene , endocrinology , medicine , insulin resistance

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.

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