Claudin and occludin expression and function in the seminiferous epithelium | Zendy

Carla M.K. Morrow | Zendy; Dolores D. Mruk | Zendy; C. Yan Cheng | Zendy; Rex A. Hess | Zendy

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Claudin and occludin expression and function in the seminiferous epithelium

Author(s) -

Carla M.K. Morrow,

Dolores D. Mruk,

C. Yan Cheng,

Rex A. Hess

Publication year - 2010

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2010.0025

Subject(s) - occludin , claudin , tight junction , microbiology and biotechnology , epithelium , biology , integral membrane protein , blood–testis barrier , barrier function , membrane protein , function (biology) , sertoli cell , endocrinology , membrane , biochemistry , genetics , spermatogenesis

Integral membrane proteins that contribute to function of the blood-testes barrier (BTB) in mice include claudins 3, 5 and 11 and occludin. Although claudin 11 is expressed throughout all stages of the seminiferous epithelial cycle, claudins 3 and 5 have specific expression at stage VIII. These differences in protein expression suggest that the interactions among, and functions of, these integral membrane proteins may shift over the course of the seminiferous epithelial cycle. Also, differences in expression among rodent species and men may make interpretation of studies across species challenging. This review will discuss the characteristics of claudins and occludin; the expression, regulation and function of these integral membrane proteins in the seminiferous epithelium; and how these properties relate to the unique features of BTB.

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