A stereospecific solid-phase screening assay for colonies expressing both ( R )- and ( S )-selective ω-aminotransferases | Zendy

Simon C. Willies | Zendy; James L. Galman | Zendy; Iustina Slabu | Zendy; Nicholas J. Turner | Zendy

Open Access

A stereospecific solid-phase screening assay for colonies expressing both ( R )- and ( S )-selective ω-aminotransferases

Author(s) -

Simon C. Willies,

James L. Galman,

Iustina Slabu,

Nicholas J. Turner

Publication year - 2016

Publication title -

philosophical transactions of the royal society a mathematical physical and engineering sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.074

H-Index - 169

eISSN - 1471-2962

pISSN - 1364-503X

DOI - 10.1098/rsta.2015.0084

Subject(s) - stereospecificity , substrate (aquarium) , high throughput screening , selectivity , phase (matter) , combinatorial chemistry , throughput , chemistry , biology , computer science , biochemistry , catalysis , organic chemistry , ecology , telecommunications , wireless

A novel solid-phase screening assay was developed for colonies expressing both (R )- and (S )-selective ω-aminotransferases. This high-throughput assay can be used to screen rapidly large variant libraries with enhanced substrate selectivity and enantioselectivities.

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