Free boundary problems in biology
Author(s) -
Avner Friedman
Publication year - 2015
Publication title -
philosophical transactions of the royal society a mathematical physical and engineering sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.074
H-Index - 169
eISSN - 1471-2962
pISSN - 1364-503X
DOI - 10.1098/rsta.2014.0368
Subject(s) - mathematical and theoretical biology , uniqueness , boundary (topology) , mathematical model , boundary value problem , free boundary problem , mathematical problem , mathematics , computer science , calculus (dental) , biology , mathematical analysis , bioinformatics , mathematics education , medicine , statistics , dentistry
In this paper, I review several free boundary problems that arise in the mathematical modelling of biological processes. The biological topics are quite diverse: cancer, wound healing, biofilms, granulomas and atherosclerosis. For each of these topics, I describe the biological background and the mathematical model, and then proceed to state mathematical results, including existence and uniqueness theorems, stability and asymptotic limits, and the behaviour of the free boundary. I also suggest, for each of the topics, open mathematical problems.
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