Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide | Zendy

John V. Garcia | Zendy; Fan Zhang | Zendy; Peter C. Ford | Zendy

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Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Author(s) -

John V. Garcia,

Fan Zhang,

Peter C. Ford

Publication year - 2013

Publication title -

philosophical transactions of the royal society a mathematical physical and engineering sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.074

H-Index - 169

eISSN - 1471-2962

pISSN - 1364-503X

DOI - 10.1098/rsta.2012.0129

Subject(s) - two photon excitation microscopy , excitation , photon , excited state , photochemistry , molecule , absorption (acoustics) , ultraviolet , materials science , chemistry , lanthanide , ion , optoelectronics , atomic physics , optics , physics , organic chemistry , quantum mechanics , composite material

Multi-photon excitation allows one to use tissue transmitting near-infrared (NIR) light to access excited states with energies corresponding to single-photon excitation in the visible or ultraviolet wavelength ranges. Here, we present an overview of the application of both simultaneous and sequential multi-photon excitation in studies directed towards the photochemical delivery ('uncaging') of bioactive small molecules such as nitric oxide (NO) to physiological targets. Particular focus will be directed towards the use of dyes with high two-photon absorption cross sections and lanthanide ion-doped upconverting nanoparticles as sensitizers to facilitate the uncaging of NO using NIR excitation.

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