Structure and biological activity of glasses and ceramics

Biomaterials for repairing and regenerating parts of the human body play a key role in contemporary medicine, and have an increasing impact in modern society. Given the importance of orthopaedic medicine (bone is the second most replaced organ after blood), bioactive glasses and ceramics represent a key reference to guide technological advances in this field. Their established role in current biomedical applications has already led many research groups worldwide to look into their structural properties, with a view to identifying the molecular basis of their biological activity. As the efforts directed towards this crucial and exciting direction continue to increase, it is now timely to review the situation, in order to guide future investigations on structure-bioactivity relationships. In this introductory article, the field is reviewed, to provide an appropriate context for the contributions to this Theme Issue.