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In 1827, or forty-one years ago, the phenomenon which forms the subject of this paper was first observed by Mr. Joseph Jackson Lister and the late Dr. Hodgkin. To these observers the microscope revealed the fact that if a minute drop of human blood is placed between two plates of glass, the red corpuscles apply themselves to each other by their concave surfaces in such a manner as to form long cylindrical masses, which resemble piles of coin, and that very frequently these piles are so arranged as to form with each other a complete network of rouleaux with clear intervening spaces occupied by liquor sanguinis.

I. On the laws and principles concerned in the aggregation of blood-corpuscles both within and without the vessels