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Brain metabolic rate (MR) is linked mainly to the cost of synaptic activity, so may be a better correlate of cognitive ability than brain size alone. Among primates, the sizes of arterial foramina in recent and fossil skulls can be used to evaluate brain blood flow rate, which is proportional to brain MR. We use this approach to calculate flow rate in the internal carotid arteries , which supply most of the primate cerebrum.  is up to two times higher in recent gorillas, chimpanzees and orangutans compared with 3-million-year-old australopithecine human relatives, which had equal or larger brains. The scaling relationships between  and brain volume () show exponents of 1.03 across 44 species of living haplorhine primates and 1.41 across 12 species of fossil hominins. Thus, the evolutionary trajectory for brain perfusion is much steeper among ancestral hominins than would be predicted from living primates. Between 4.4-million-year-old  and ,  increased 4.7-fold, but  increased 9.3-fold, indicating an approximate doubling of metabolic intensity of brain tissue. By contrast,  is proportional to  among haplorhine primates, suggesting a constant volume-specific brain MR.

Cerebral blood flow rates in recent great apes are greater than in Australopithecus species that had equal or larger brains