Molecular analysis of ancient caries | Zendy

Marc Simón | Zendy; Rafaél Montiel | Zendy; Andrea Smerling | Zendy; Eduvigis Solórzano | Zendy; Nancy Díaz | Zendy; Brenda A. Álvarez-Sandoval | Zendy; Andrea R. Jiménez-Marín | Zendy; Assumpció Malgosa | Zendy

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Molecular analysis of ancient caries

Author(s) -

Marc Simón,

Rafaél Montiel,

Andrea Smerling,

Eduvigis Solórzano,

Nancy Díaz,

Brenda A. Álvarez-Sandoval,

Andrea R. Jiménez-Marín,

Assumpció Malgosa

Publication year - 2014

Publication title -

proceedings of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.342

H-Index - 253

eISSN - 1471-2954

pISSN - 0962-8452

DOI - 10.1098/rspb.2014.0586

Subject(s) - ancient dna , haplotype , biology , population , evolutionary biology , colonization , genetics , geography , demography , microbiology and biotechnology , allele , gene , sociology

An 84 base pair sequence of the Streptococcus mutans virulence factor, known as dextranase, has been obtained from 10 individuals from the Bronze Age to the Modern Era in Europe and from before and after the colonization in America. Modern samples show four polymorphic sites that have not been found in the ancient samples studied so far. The nucleotide and haplotype diversity of this region have increased over time, which could be reflecting the footprint of a population expansion. While this segment has apparently evolved according to neutral evolution, we have been able to detect one site that is under positive selection pressure both in present and past populations. This study is a first step to study the evolution of this microorganism, analysed using direct evidence obtained from ancient remains.

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