The length–tension curve in muscle depends on lattice spacing | Zendy

C. David Williams | Zendy; Mary K. Salcedo | Zendy; Thomas C. Irving | Zendy; Michael Regnier | Zendy; Thomas L. Daniel | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The length–tension curve in muscle depends on lattice spacing

Author(s) -

C. David Williams,

Mary K. Salcedo,

Thomas C. Irving,

Michael Regnier,

Thomas L. Daniel

Publication year - 2013

Publication title -

proceedings of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.342

H-Index - 253

eISSN - 1471-2954

pISSN - 0962-8452

DOI - 10.1098/rspb.2013.0697

Subject(s) - tension (geology) , lattice (music) , materials science , biophysics , chemistry , physics , composite material , biology , compression (physics) , acoustics

Classic interpretations of the striated muscle length-tension curve focus on how force varies with overlap of thin (actin) and thick (myosin) filaments. New models of sarcomere geometry and experiments with skinned synchronous insect flight muscle suggest that changes in the radial distance between the actin and myosin filaments, the filament lattice spacing, are responsible for between 20% and 50% of the change in force seen between sarcomere lengths of 1.4 and 3.4 µm. Thus, lattice spacing is a significant force regulator, increasing the slope of muscle's force-length dependence.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research