Open AccessStudies on the antibacterial properties of the bile acids and some compounds derived from cholanic acid
Author(s) -
M. Stacey,
M. Webb
Publication year - 1947
Publication title -
proceedings of the royal society of london. series b, biological sciences
Language(s) - English
Resource type - Journals
eISSN - 2053-9193
pISSN - 0080-4649
DOI - 10.1098/rspb.1947.0029
Subject(s) - chemistry , staphylococcus aureus , surface tension , limiting , dilution , bacteria , organic chemistry , biology , mechanical engineering , physics , genetics , quantum mechanics , engineering , thermodynamics
In this work the bile acids and certain of their derivatives have been studied with regard to their bacteriostatic power and relative activities in removing the Gram-positive complex from yeast. No correlation between these properties was obtained. A simple relationship was apparent, however, between the bacteriostatic activities of the compounds and their ability to depress the surface tension of the metabolism medium. The limiting dilution at which the 'active' bile acids were bacteriostatic forStaphylococcus aureus corresponded to a depression of the surface tension of the medium by approximately 4∙5 dynes. The relationship between bacteriostatic power and surface activity was only valid for this particular series of compounds of closely related molecular structure.