Open AccessThe association of carcinogenicity and growth-inhibitory power in the polycyclic hydrocarbons and other substances
Author(s) -
Alexander Haddow,
A. Robinson
Publication year - 1939
Publication title -
proceedings of the royal society of london. series b, biological sciences
Language(s) - English
Resource type - Journals
eISSN - 2053-9193
pISSN - 0080-4649
DOI - 10.1098/rspb.1939.0022
Subject(s) - carcinogen , chemistry , inhibitory postsynaptic potential , toxicology , biology , biochemistry , endocrinology
Previous papers (Haddow 1935, 1938a ; Haddow and Robinson 1937; Haddow, Scott and Scott 1937) described the growth-inhibitory action of many carcinogenic hydrocarbons and the absence of this property in numerous non-carcinogenic compounds of somewhat different structure. The possible implications of this association, concerning the mode of action of cancer-producing substances, have already been discussed (Haddow 1938b ), but the investigation was extended so as to include certain of the benzanthracene homologues which have been found inactive in tests for carcinogenic potency. Since such compounds are of course more closely related to the carcinogenic compounds than many of the non-carcinogenic compounds previously studied, such an investigation represents a rather more searching test of the hypothesis that carcinogenicity is dependent on growth-inhibitory power.