Open AccessThe production of cancer by pure hydrocarbons —Part III
Author(s) -
Geraldine Barry,
J. W. Cook,
G. A. D. Haslewood,
C. L. Hewett,
I. Hieger,
E. L. Kennaway
Publication year - 1935
Publication title -
proceedings of the royal society of london. series b, biological sciences
Language(s) - English
Resource type - Journals
eISSN - 2053-9193
pISSN - 0080-4649
DOI - 10.1098/rspb.1935.0032
Subject(s) - benzene , benzanthracene , chemistry , carcinogen , toxicology , organic chemistry , biology
The carcinogenic properties of 1: 2: 5: 6-dibenzanthracene, 5: 6-cyclo -penteno-1: 2-benzanthracene and some closely related compounds have already been described (Part I, Cook, Hieger, Kennaway and Mayneord, 1932; Part II, Cook, 1932,a ; Burrows, Hieger and Kennaway, 1932; Burrows, 1932 and 1933; Barry and Cook, 1934). The present communication records the results of a systematic examination for carcinogenic activity of tetracyclic and pentacyclic aromatic hydrocarbons, and also deals with the extension of this work along lines suggested by the results obtained. Technique (1) Tests for the production of cancer of the skin were carried out by applying the substance in solution to the interscapular region of mice twice weekly. In the great majority of cases the compound was applied in benzene (0·3 gm in 100 cc), whether this gave a saturated solution or not. The advantages and disadvantages of this method have been discussed in an earlier paper (Part I). Any other concentrations or solvents used are stated in the tables below. The results are shown in Tables I-IX.