Open AccessElectrometric titration of amino-acids in aqueous-alcoholic solution
Author(s) -
A. Neuberger
Publication year - 1934
Publication title -
proceedings of the royal society of london. series b, containing papers of a biological character
Language(s) - English
Resource type - Journals
eISSN - 2053-9185
pISSN - 0950-1193
DOI - 10.1098/rspb.1934.0035
Subject(s) - zwitterion , betaine , aqueous solution , strong acids , ionic bonding , chemistry , titration , amino acid , molecule , chemical physics , computational chemistry , organic chemistry , inorganic chemistry , ion , biochemistry
The conception that substances exist which carry both positive and negative charges in the same molecule was first advanced by Bredig (1894) and Küster (1897) in connection with betaine and methyl orange respectively. Küster designated such substances zwitterions; since, however, these particular compounds fail to exhibit the essential ionic property of migration in an electric field they should rather be called zwittermolecules. Later Bredig (1899) extended the conception to the aliphatic amino-acids, and the theory was agin taken up in an interesting paper by Adams (1916); the most convincing arguments in its favour were, however, supplied by Bjerrum (1923). In the meantime the results of many investigations had afforded additional support for the hypothesis; the more essential of these have been discussed by Richardson (p. 121) and may be summarized as follows.