Open AccessOvarian regeneration in the mouse after complete double ovariotomy
Author(s) -
A. S. Parkes,
F. W. Rogers Brambell
Publication year - 1927
Publication title -
proceedings of the royal society of london. series b, containing papers of a biological character
Language(s) - English
Resource type - Journals
eISSN - 2053-9185
pISSN - 0950-1193
DOI - 10.1098/rspb.1927.0019
Subject(s) - regeneration (biology) , ovary , ovarian tissue , guinea pig , compensatory hypertrophy , muscle hypertrophy , biology , andrology , anatomy , medicine , endocrinology , microbiology and biotechnology
The fact that after unilateral ovariotomy the remaining ovary hypertrophies and undertakes the work of two ovaries has been recognised for many years (Carmichael and Marshall (6), Arai (2), Lipschütz and Adamberg (14)), and in the same way it has been found that ovarian fragments are capable of undergoing intensive hypertrophy to produce appreciable amounts of ovarian tissue (Asdell (3), Hartmann (12), Lipschütz (13)). The regeneration of ovarian tissue after complete double ovariotomy, however, has until recently rarely been considered as a serious possibility, the evidence that such re-formation can take place having been scanty and usually explained on the grounds of incomplete removal of the ovaries. In 1911 Castle and Phillips (7) reported 10 cases of ovarian regeneration after ovariotomy among 74 guinea-pigs and 17 rabbits, and in three of these young were produced. Subsequently, the authors (5) state that of a total of 141 ovariotomised guinea-pigs, 11, of which three produced young, showed regeneration of ovarian tissue. They also note that in cases of ovarian regeneration the usual ovariotomy effects are not found.