Open AccessLactic acid in mammalian cardiac muscle.— Part III. changes in hydrogen-ion concentration. (Preliminary note.)
Author(s) -
L. N. Katz,
C. N. H. Long
Publication year - 1925
Publication title -
proceedings of the royal society of london. series b, containing papers of a biological character
Language(s) - English
Resource type - Journals
eISSN - 2053-9185
pISSN - 0950-1193
DOI - 10.1098/rspb.1925.0065
Subject(s) - hydrogen ion , lactic acid , hydrogen , anaerobic exercise , ion , skeletal muscle , cardiac muscle , saline , chemistry , stimulation , rigor mortis , ph meter , biomedical engineering , materials science , biochemistry , medicine , anatomy , biology , physiology , bacteria , organic chemistry , genetics
Experiments have been made to determine (1) the hydrogen-ion concentrations of cardiac and skeletal muscle minced in the cold (a ) under normal conditions, (b )after stimulation to fatigue, and (c ) in rigor mortis, and (2) the change of hydrogen-ion concentration following the addition of known amounts of lactic acid. The measurements were made by means of the glass electrode method (Kerridge (1)). The results given are quantitatively only preliminary in character, pending (i) the repetition of the experiments on a larger number of animals, and (ii) the more accurate estimation of corrections due to dilution with saline, &c.