Open AccessThe effect of reaction changes on human inorganic metabolism
Author(s) -
J. B. S. Haldane,
V. B. Wigglesworth,
C. E. Woodrow
Publication year - 1924
Publication title -
proceedings of the royal society of london. series b, containing papers of a biological character
Language(s) - English
Resource type - Journals
eISSN - 2053-9185
pISSN - 0950-1193
DOI - 10.1098/rspb.1924.0007
Subject(s) - excretion , sodium bicarbonate , chemistry , net acid excretion , sodium , potassium , bicarbonate , urine , acidosis , ingestion , phosphate , metabolic acidosis , inorganic chemistry , ammonium , endocrinology , medicine , biochemistry , organic chemistry
Phosphate must be present in the urine to allow of the excretion of appreciable quantities of acid at a low hydrogen ion concentration, and Fitz, Alsberg and Henderson (1) showed that the urinary phosphate excretion is raised in acidosis. Some of the experiments here described were undertaken to determine the cause of this excretion. A study of the water, sodium and potassium excretion in acidosis was also made. The reaction of the body was made more acid either by breathing 6 to 7 per cent. CO2 or by taking ammonium chloride ; more alkaline by over-breathing or sodium bicarbonate ingestion. Phosphates were estimated as described by Wigglesworth and Woodrow (2).