Open AccessThe action of "peptone" on blood and immunity thereto
Publication year - 1922
Publication title -
proceedings of the royal society of london. series b, containing papers of a biological character
Language(s) - English
Resource type - Journals
eISSN - 2053-9185
pISSN - 0950-1193
DOI - 10.1098/rspb.1922.0026
Subject(s) - antithrombin , chemistry , immunity , action (physics) , statement (logic) , medicine , endocrinology , immunology , biology , biochemistry , immune system , philosophy , heparin , physics , quantum mechanics , epistemology
The current view on the cause of the non-coagulability of the blood after the injection of “peptone” is that the injected material stimulates the liver (or the liver plus other organs) to form an excess of a substance named antithrombin. The liver is considered further to form antithrombin under normal conditions in amount sufficient to maintain the fluidity of the blood. The statement that “peptone” which follows its slow injection is commonly ascribed to hepatic activity. The experiments recorded in this paper show that these views can no longer be held.