The viability of human carcinoma in animals

The object of the present research is to determine the cell changes occurring in portions of human carcinoma implanted into animals, and more particularly to ascertain if such implanted tissues are capable of surviving for timing, and if so, the manner in which they succumb. Implantation of human carcinoma into animals has been made by numerous observes, and the failure of such implantations to produce tumours is now an ascertained fact. Among the earliest experiments are those of Ballance and Shattock, the objective of which was to determine if human carcinoma was transferable from man to animals; in these observations the immediate effect of implantation upon the cells of the growth was not determined. Von Langenbeck, Jürgens, Dagonet and Mauclaire, and Gaylord produced in animals, by inoculation of carcinoma, tumours which, however, differed in structure in dogs by implantation of a human ovaroan carcinoma, and also in rats by inoculation of a carcinoma of the cervix of the human uterus; this another made numerous attempts to obtain inoculable tissues by implantation of human carcinoma, but only the above two were successful.