On the distribution and action of soluble substances in frogs deprived of their circulatory apparatus

In view of the great distributory efficiency of the cardio-vascular apparatus, no serious consideration has been given to the possibility of the existence of other modes of distribution of material in the animal body. In the following, results of experiments will be briefly presented which give unmistakable evidence of an efficient distribution of substances in cardiectomised frogs. In these experiments the heart was exposed, ligated, and removed, and the incision closed again. Such a removal of the heart eliminates also the activity of the lymph vessels and the lymph hearts which empty their contents into veins. Injections were given into the various lymph sacs of the body and into the abdominal cavity. The results to be reported were derived from experiments made with three alkaloids presenting different types: adrenaline, strychnine, and morphine.