Open AccessThe experimental treatment of trypanosomiasis in animals
Publication year - 1905
Publication title -
proceedings of the royal society of london. series b, containing papers of a biological character
Language(s) - English
Resource type - Journals
eISSN - 2053-9185
pISSN - 0950-1193
DOI - 10.1098/rspb.1905.0051
Subject(s) - arsenic trioxide , arsenic , trypanosomiasis , medicine , trypan blue , arsenic poisoning , sloughing , pharmacology , surgery , veterinary medicine , chemistry , pathology , biochemistry , organic chemistry , in vitro
Numerous drugs have been tried in endeavouring to find a therapeutical agent which would cause trypanosomes to disappear from the blood. Of all those tried, arsenic and trypan red are the only ones exhibiting a marked influence on the parasites. On account of the liability of the appearance of toxic symptoms, the proneness to sloughing at the site of inoculation, and the oftentimes considerable disturbance which occurred after the subcutaneous administration of sodium arseniate, I decided to try if other compounds would be more satisfactory in the treatment of trypanosomiasis. The arsenic preparation which has given the best results is a compound of arsenic and aniline C6 H5 No2 As (meta-arsensaure anilid, atoxyl), a preparation which has of recent years been used intravenously and subcutaneously in the treatment of skin diseases and anæmia.