Facile synthesis of 2-arylimidazo[1,2-a]pyridines catalysed by DBU in aqueous ethanol | Zendy

Babita Veer | Zendy; Ram Singh | Zendy

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Facile synthesis of 2-arylimidazo[1,2-a]pyridines catalysed by DBU in aqueous ethanol

Author(s) -

Babita Veer,

Ram Singh

Publication year - 2019

Publication title -

proceedings of the royal society a mathematical physical and engineering sciences

Language(s) - English

Resource type - Journals

eISSN - 1471-2946

pISSN - 1364-5021

DOI - 10.1098/rspa.2019.0238

Subject(s) - chemistry , yield (engineering) , ethanol , solvent , aqueous solution , substrate (aquarium) , organic chemistry , aminopyridines , medicinal chemistry , materials science , oceanography , metallurgy , geology

A facile protocol for the synthesis of 2-arylimidazo[1,2-a]pyridines was developed using two-component cyclization of substituted 2-aminopyridines and substituted phenacyl bromides in 65–94% yield. The reaction was DBU catalysed using green solvent, aqueous ethanol (1 : 1 v/v) at room temperature. The atom economy of the products was calculated to be 66.25–73.41%. The developed protocol successfully exhibits a broad substrate scope, less reaction time, high to moderate yield and multigram scale synthesis.

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