How big is an outbreak likely to be? Methods for epidemic final-size calculation
Author(s) -
Thomas House,
Joshua V. Ross,
David Sirl
Publication year - 2012
Publication title -
proceedings of the royal society a mathematical physical and engineering sciences
Language(s) - English
Resource type - Journals
eISSN - 1471-2946
pISSN - 1364-5021
DOI - 10.1098/rspa.2012.0436
Subject(s) - inference , context (archaeology) , computer science , moment (physics) , outbreak , homogeneous , infectious disease (medical specialty) , mathematical optimization , econometrics , mathematics , disease , medicine , geography , artificial intelligence , virology , physics , archaeology , classical mechanics , combinatorics , pathology
Epidemic models have become a routinely used tool to inform policy on infectious disease. A particular interest at the moment is the use of computationally intensive inference to parametrize these models. In this context, numerical efficiency is critically important. We consider methods for evaluating the probability mass function of the total number of infections over the course of a stochastic epidemic, with a focus on homogeneous finite populations, but also considering heterogeneous and large populations. Relevant methods are reviewed critically, with existing and novel extensions also presented. We provide code in M atlab and a systematic comparison of numerical efficiency.
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