The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids | Zendy

Siyuan Cheng | Zendy; Weiwei Zhao | Zendy; Xinan Yang | Zendy; Ye Meng | Zendy; Liantong Wei | Zendy; Zhu Tao | Zendy; Peihua Ma | Zendy

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The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids

Author(s) -

Siyuan Cheng,

Weiwei Zhao,

Xinan Yang,

Ye Meng,

Liantong Wei,

Zhu Tao,

Peihua Ma

Publication year - 2021

Publication title -

royal society open science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.84

H-Index - 51

ISSN - 2054-5703

DOI - 10.1098/rsos.202120

Subject(s) - isothermal titration calorimetry , cucurbituril , amino acid , lysine , glycine , leucine , chemistry , titration , alkyl , crystallography , stereochemistry , biochemistry , supramolecular chemistry , crystal structure , organic chemistry

Binding behaviours between cyclopentanocucurbit[6]uril (CyP 6 Q[6]) and three amino acids have been investigated by means of X-ray crystallography, proton nuclear magnetic resonance spectroscopy and isothermal titration calorimetry. The results showed that CyP 6 Q[6] forms a 1 : 2 inclusion complex with glycine, but 1 : 1 complexes with both leucine and lysine. Whereas the carboxyl group of glycine can enter the interior of the cavity of CyP 6 Q[6], only the alkyl chains of leucine and lysine can enter this cavity. Interestingly, leucine can adopt two different self-assembly modes upon its interaction with cucurbituril, depending on the external conditions, whereas glycine and lysine do not exhibit such behaviour.

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