Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry | Zendy

Christopher Johnston | Zendy; Christopher Hardacre | Zendy; Marie E. Migaud | Zendy

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Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry

Author(s) -

Christopher Johnston,

Christopher Hardacre,

Marie E. Migaud

Publication year - 2021

Publication title -

royal society open science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.84

H-Index - 51

ISSN - 2054-5703

DOI - 10.1098/rsos.201703

Subject(s) - phosphoramidite , mechanochemistry , nucleoside , chemistry , reagent , dimer , nucleotide , mixing (physics) , combinatorial chemistry , organic chemistry , stereochemistry , oligonucleotide , biochemistry , dna , physics , quantum mechanics , gene

Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.

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