Open AccessInvestigating the interaction of terbinafine with xanthenes dye for its feasible determination applying the resonance Rayleigh scattering technique
Author(s) -
Mohamed A. AbdelLateef,
Sayed M. Derayea,
Deena A.M. Nour El-Deen,
Albandary Almahri,
Mohamed Oraby
Publication year - 2021
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.201545
Subject(s) - terbinafine , chemistry , chromatography , detection limit , hydrochloride , solvent , buffer solution , nuclear chemistry , organic chemistry , antifungal , medicine , itraconazole , dermatology
Terbinafine hydrochloride is a potent antifungal drug indicated for oral and topical treatment of mycoses. A resonance Rayleigh scattering (RRS) method was developed for the determination of terbinafine hydrochloride through a feasible complexation reaction with erythrosine B. In a weakly acidic medium (acetate buffer, pH 5.0), terbinafine hydrochloride can react with erythrosine B through the electrostatic attraction and virtue of hydrophobic force to form an ion-association complex. The reaction resulted in the appearance of a new RRS peak at 369 nm. The RRS peak was increased by increasing the concentration of terbinafine hydrochloride in the linear range of 0.1–1.5 µg ml −1 . All the reaction conditions (erythrosine B concentration, buffer volume, diluting solvent and pH) were optimized. The detection limit was 0.029 µg ml −1 while the quantitation limit was 0.089 µg ml −1 . The suggested method after its validation was successfully applied for the determination of terbinafine hydrochloride in different pharmaceutical formulations (tablets and cream) with sufficient recovery.