Enhancement in the antibacterial activity of cephalexin by its delivery through star-shaped poly(ε-caprolactone)-block-poly(ethylene oxide) coated silver nanoparticles | Zendy

Sana Rahim | Zendy; Samina Perveen | Zendy; Shakil Ahmed | Zendy; Muhammad Raza Shah | Zendy; Muhammad Imran Malik | Zendy

Open Access

Enhancement in the antibacterial activity of cephalexin by its delivery through star-shaped poly(ε-caprolactone)-block-poly(ethylene oxide) coated silver nanoparticles

Author(s) -

Sana Rahim,

Samina Perveen,

Shakil Ahmed,

Muhammad Raza Shah,

Muhammad Imran Malik

Publication year - 2020

Publication title -

royal society open science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.84

H-Index - 51

ISSN - 2054-5703

DOI - 10.1098/rsos.201097

Subject(s) - antibacterial activity , caprolactone , nuclear chemistry , ethylene oxide , silver nanoparticle , chemistry , minimum inhibitory concentration , zeta potential , drug delivery , fourier transform infrared spectroscopy , nanoparticle , copolymer , nanotechnology , materials science , antimicrobial , chemical engineering , bacteria , organic chemistry , polymer , genetics , engineering , biology

The antibacterial activity of silver nanoparticles (AgNPs) stabilized with a four-armed star-shaped poly(ε-caprolactone)-block-poly(ethylene oxide) copolymer [St-P(CL-b-EO)] and its application as a drug delivery vehicle for cephalexin (Cp) was evaluated against pathogenic Staphylococcus aureus . The prepared AgNPs were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, zeta sizer and atomic force microscopy (AFM). The antibacterial efficiency of Cp is enhanced several-fold by its delivery through complexation with St-P(CL-b-EO)-AgNPs, monitored by microplate assay and biofilm destruction studies. Finally, the visual destruction of bacterial cells and its biofilms by employing Cp and its conjugates at their minimum inhibitory concentration (MIC 50 ) and minimum biofilm inhibitory concentration (MBIC 50 ), respectively, is observed by topographic imaging by AFM. Enhanced antibacterial activity of St-P(CL-b-EO)-AgNPs loaded Cp is attributed to penetrative nature of the drug cargo St-P(CL-b-EO)-AgNPs towards the bacterial cell wall.

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