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HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from N  ɛ  -acetyl lysine. In the current study, we raised a novel design, which concerns N  ɛ  -acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.

N ɛ -acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors

N ^ɛ -acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors