Open AccessN ɛ -acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors
Author(s) -
Fang Wang,
Chun Wang,
Jie Wang,
Yefang Zou,
Xiaoxue Chen,
Ting Liu,
Yan Li,
YongLong Zhao,
Yongjun Li,
Bin He
Publication year - 2019
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.190338
Subject(s) - lysine , acetylation , amide , zinc , chemistry , combinatorial chemistry , stereochemistry , biochemistry , amino acid , gene , organic chemistry
HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from N ɛ -acetyl lysine. In the current study, we raised a novel design, which concerns N ɛ -acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.
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