Open AccessGentamicin-loaded silk/nanosilver composite scaffolds for MRSA-induced chronic osteomyelitis
Author(s) -
Peng Zhang,
Jiaqi Qin,
Bo Zhang,
Yi Zheng,
Lingyan Yang,
Yixin Shen,
Baoqi Zuo,
Feng Zhao
Publication year - 2019
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.182102
Subject(s) - gentamicin , osteomyelitis , staphylococcus aureus , composite number , formic acid , methicillin resistant staphylococcus aureus , antibiotics , silk , materials science , in vivo , antimicrobial , medicine , microbiology and biotechnology , chemistry , bacteria , composite material , surgery , biology , genetics , chromatography
Methicillin-resistant Staphylococcus aureus (MRSA) often induces chronic osteomyelitis and then bone defects. Here, gentamicin-loaded silk/nanosilver composite scaffolds were developed to treat MRSA-induced chronic osteomyelitis. AgNO 3 was reduced with silk as a reducing agent in formic acid, forming silver nanoparticles in situ that were distributed uniformly in the composite scaffolds. Superior antibacterial properties against MRSA were achieved for the composite scaffolds, without the compromise of osteogenesis capacity. Then gentamicin was loaded on the scaffolds for better treatment of osteomyelitis. In vivo results showed effective inhibition of the growth of MRSA bacteria, confirming the promising future in the treatment of chronic osteomyelitis.