Open AccessBursts of amino acid replacements in protein evolution
Author(s) -
Anastasia V Stolyarova,
Georgii A. Bazykin,
Tatiana V. Neretina,
Alexey S. Kondrashov
Publication year - 2019
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.181095
Subject(s) - protein evolution , molecular evolution , interval (graph theory) , amino acid substitution , evolutionary biology , rate of evolution , biology , positive selection , selection (genetic algorithm) , amino acid , genetics , computer science , phylogenetics , gene , mathematics , mutation , artificial intelligence , combinatorics
Evolution can occur both gradually and through alternating episodes of stasis and rapid changes. However, the prevalence and magnitude of fluctuations of the rate of evolution remain obscure. Detecting a rapid burst of changes requires a detailed record of past evolution, so that events that occurred within a short time interval can be identified. Here, we use the phylogenies of the Baikal Lake amphipods and of Catarrhini, which contain very short internal edges which make this task feasible. We detect six salient bursts of evolution of individual proteins during such short time periods, each involving between six and 38 amino acid substitutions. These bursts were extremely unlikely to have occurred neutrally, and were apparently caused by positive selection. On average, in the course of a time interval required for one synonymous substitution per site, a protein undergoes a strong burst of rapid evolution with probability at least approximately 0.01.