Open AccessCopper-catalysed regioselective sulfenylation of indoles with sodium sulfinates
Author(s) -
Xiaojun Luo,
Qiang Liu,
Hongxia Zhu,
Huoji Chen
Publication year - 2018
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.180170
Subject(s) - regioselectivity , formamide , copper , chemistry , sodium , organic chemistry , functional group , solvent , combinatorial chemistry , catalysis , polymer
A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in N , N -dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant. This transformation is easy to carry out and has mild reaction conditions and good functional group tolerance.
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