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Leishmaniasis is a vector-borne protozoan disease; it mainly originates from the bite of sandfly and initiated when parasite is transmitted to human at metacyclic flagellated promastigote form. In the current study, a synthesis of a series of 4-substituted benzophenone ethers  1–20  was carried out in good yields and their  in vitro  antileishmanial activities were also screened. Among synthetic derivatives, 15 compounds  1 ,  3 ,  5–12 ,  15  and  17 – 20  showed antileishmanial activities against promastigotes of  Leishmania major  with IC 50  values in the range of 1.19–82.30 µg ml −1 , and the values were compared with those of the standard pentamidine (IC 50  = 5.09 ± 0.09 µg ml −1 ). Our study identified a series of new antileishmanial molecules as potential leads. Structures of these synthetic compounds were deduced by different spectroscopic techniques, such as  1 H and  13 C nuclear magnetic resonance, electron impact and high-resolution electron impact mass spectrometry and IR.

Synthesis of 4-substituted ethers of benzophenone and their antileishmanial activities