Open AccessConstruction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes
Author(s) -
Yanwei Cao,
Xiaoxuan Xiang,
Renjun Pei,
Yang Li,
Yuting Yan,
Xinhua Guo
Publication year - 2017
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.171337
Subject(s) - nanostructure , dna , g quadruplex , duplex (building) , nanotechnology , materials science , chemistry , biochemistry
A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadruplexes and i-motifs in weakly acidic potassium acetate solution, which leads to the assembly of DNA nanostructures composed of alternating quadruplex and duplex DNA structures. The transformation between different DNA nanoarchitectures may be applied to the operation of ‘DNA nanomachines’.