Open AccessAmadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
Author(s) -
Taiki Miyazawa,
Reina Kamiyoshihara,
Naoki Shimizu,
Takahiro Harigae,
Yurika Otoki,
Junya Ito,
Shunji Kato,
Teruo Miyazawa,
Kiyotaka Nakagawa
Publication year - 2018
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.171249
Subject(s) - phosphatidylethanolamine , amadori rearrangement , liposome , phosphatidylcholine , chemistry , membrane , glycation , biochemistry , receptor , phospholipid
Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.