Open AccessSemisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety
Author(s) -
Yong Guo,
Xiaoguang Wang,
Jie Fan,
Qian Zhang,
Yi Wang,
Yi Zhao,
Mengxing Huang,
Ming Ding,
Yanbing Zhang
Publication year - 2017
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.171053
Subject(s) - mythimna separata , semisynthesis , moiety , oxadiazole , stereochemistry , chemistry , biology , larva , organic chemistry , botany
Two series of novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety were prepared as insecticidal agents against the oriental armyworm, Mythimna separata Walker. The structural assignment was based on the spectroscopic and X-ray analysis data. Among all the target compounds, compounds 4b , 4k , 5b , 5j and 5k exhibited more potent insecticidal activity with final mortality rates (FMRs) of more than 65%, especially 4k with the FMR of 75.9%, when compared with toosendanin. Some interesting results of structure–activity relationships are also discussed.