Semisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety | Zendy

Yong Guo | Zendy; Xiaoguang Wang | Zendy; Jiangping Fan | Zendy; Qian Zhang | Zendy; Yi Wang | Zendy; Yi Zhao | Zendy; Mengxing Huang | Zendy; Ming Ding | Zendy; Yanbing Zhang | Zendy

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Semisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety

Author(s) -

Yong Guo,

Xiaoguang Wang,

Jiangping Fan,

Qian Zhang,

Yi Wang,

Yi Zhao,

Mengxing Huang,

Ming Ding,

Yanbing Zhang

Publication year - 2017

Publication title -

royal society open science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.84

H-Index - 51

ISSN - 2054-5703

DOI - 10.1098/rsos.171053

Subject(s) - mythimna separata , semisynthesis , moiety , oxadiazole , stereochemistry , chemistry , biology , larva , organic chemistry , botany

Two series of novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety were prepared as insecticidal agents against the oriental armyworm, Mythimna separata Walker. The structural assignment was based on the spectroscopic and X-ray analysis data. Among all the target compounds, compounds 4b , 4k , 5b , 5j and 5k exhibited more potent insecticidal activity with final mortality rates (FMRs) of more than 65%, especially 4k with the FMR of 75.9%, when compared with toosendanin. Some interesting results of structure–activity relationships are also discussed.

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