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A new series of indole-based pyranoquinoline derivatives  P 1–24   has been synthesized by a one-pot cyclocondensation reaction of 2-(4-substituted)phenyl- N -allyl-indole-3-carbaldehydes  1a–d ; active methylenes  2a–c ; and 4-hydroxy-1-substituted quinolin-2(1 H )-one  3a–b  catalysed by an organocatalyst tetra- n -butylammonium fluoride (TBAF) in aqueous ethanol. The easy experimental procedure of the reaction leads to excellent yields of pyranoquinoline derivatives. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than standard drugs as evident from the structural activity relationship study.

royal society open science

An efficient synthesis of 4 <i>H</i> -pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra- <i>n</i> -butylammonium fluoride and their pharmacological screening

An efficient synthesis of 4 H -pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra- n -butylammonium fluoride and their pharmacological screening