Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies | Zendy

Pakinaz Y. Khashaba | Zendy; Hassan Refat H. Ali | Zendy; Mohamed M. ElWekil | Zendy

Open Access

Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies

Author(s) -

Pakinaz Y. Khashaba,

Hassan Refat H. Ali,

Mohamed M. ElWekil

Publication year - 2017

Publication title -

royal society open science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.84

H-Index - 51

ISSN - 2054-5703

DOI - 10.1098/rsos.170324

Subject(s) - pantoprazole , chemistry , detection limit , fourier transform infrared spectroscopy , voltammetry , linear range , analytical chemistry (journal) , chromatography , electrode , materials science , electrochemistry , chemical engineering , medicine , engineering , omeprazole

A pencil graphite electrode modified with poly (bromocresol green (BCG)) was prepared by electro-polymerization process for the determination of pantoprazole sodium. The surface morphology and structure of poly (BCG) film were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The determination of pantoprazole sodium in Britton–Robinson buffer (pH 7.0) was carried out by square wave adsorptive stripping voltammetric technique. Under optimum conditions, the linear response of the peak with concentration of the cited drug was in the range of 6.6–360 × 10 −8 M with limit of detection of 2.2 × 10 −8 M. Moreover, the poly (BCG)-modified electrode has been successfully applied to determine pantoprazole sodium in tablets, vials and during pharmacokinetic studies.

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